{"id":4355,"date":"2019-05-26T14:52:54","date_gmt":"2019-05-26T07:52:54","guid":{"rendered":"http:\/\/stang.sc.mahidol.ac.th\/newresources\/?p=4355"},"modified":"2019-05-26T14:52:54","modified_gmt":"2019-05-26T07:52:54","slug":"proteins-crossing-membranes-a-scientists-memoir","status":"publish","type":"post","link":"https:\/\/stang.sc.mahidol.ac.th\/newresources\/?p=4355","title":{"rendered":"Proteins crossing membranes : a scientist’s memoir"},"content":{"rendered":"

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AUTHOR :\u00a0 <\/strong>Rothman, S. S. (Stephen S.)<\/p>\n

CALL NO :<\/strong>\u00a0 QU55.7 R846p 2019<\/p>\n

IMPRINT :<\/strong>\u00a0\u00a0 Boca Raton, Fla. : CRC Press, c2019<\/p>\n

In an intriguing series of experiments carried out many years ago, a common scientific belief, feted by no less than three Nobel prizes, was brought into question. The observations were about proteins\u2014the molecules that the genetic code specifies and that are in one way or another central to all of life\u2019s activities. The experiments however were not about what proteins do, but how they are moved, in particular how they are moved from where they are made to where they act.\u3000The results of these studies conflicted with the standard view of how this happens, and thus became controversial.<\/p>\n

The standard view, the vesicle theory of protein secretion, envisions proteins being carried within and out of cells en masse in membrane-bound sacs or vesicles. The controversial experiments demonstrated that to the contrary individual protein molecules cross the relevant membranes as a result of their own motion. This was thought to be impossible at the time. Proteins Crossing Membranes\u3000is a personal narrative that tells the story of the controversy. Among other things, the author illustrates that scientists, like the rest of us, can rigidly hold onto their beliefs despite evidence that they are misguided.<\/p>\n

Key Features<\/p>\n