{"id":5104,"date":"2019-10-25T13:54:26","date_gmt":"2019-10-25T06:54:26","guid":{"rendered":"http:\/\/stang.sc.mahidol.ac.th\/newresources\/?p=5104"},"modified":"2019-10-25T13:54:26","modified_gmt":"2019-10-25T06:54:26","slug":"ion-channels-a-laboratory-manual","status":"publish","type":"post","link":"https:\/\/stang.sc.mahidol.ac.th\/newresources\/?p=5104","title":{"rendered":"Ion channels : a laboratory manual"},"content":{"rendered":"<p><a href=\"https:\/\/library.mahidol.ac.th\/record=b1481731a\" target=\"_blank\" rel=\"noopener noreferrer\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft wp-image-5082 size-medium\" src=\"http:\/\/stang.sc.mahidol.ac.th\/newresources\/wp-content\/uploads\/2019\/10\/66512-230x300.jpg\" alt=\"\" width=\"230\" height=\"300\" \/><\/a><\/p>\n<p><strong>AUTHOR <\/strong>:\u00a0 &#8211;<\/p>\n<p><strong>CALL NO <\/strong>:\u00a0 QH603.I54 I64 2017<\/p>\n<p><strong>IMPRINT <\/strong>:\u00a0\u00a0 Cold Spring Harbor, NY : Cold Spring Harbor Laboratory Press, c2017<!--more--><\/p>\n<p>The propagation of information through the nervous system depends on rapid changes in the electrical potential across excitable cell membranes and the generation of action potentials\u2014the fundamental unit of neuronal communication. Changes in membrane potential occur when ion channels\u2014pore-forming membrane proteins\u2014open to facilitate the passage of specific ions (e.g., Na+, K+) across the cell membrane in response to a stimulus. Defects in ion channels can lead to a wide range of diseases of the nervous system.<\/p>\n<p>This laboratory manual provides state-of-the-art techniques for investigating ion channel properties and function, particularly in the nervous system. Contributors present electrophysiological methods to examine single-channel activity in cultured cells, to study synaptic plasticity and circuit dynamics in brain slice preparations, and to perform whole-cell recordings in awake and freely moving animals. The use of optogenetic tools to study cellular and circuit dynamics in organotypic slice cultures is also covered. Many of the protocols can be adapted for other ion channels, cell types, and experimental preparations.<\/p>\n<p>The manual includes background on the structure, function, and regulation of different voltage- and ligand-gated ion channels. Therefore, it is a useful resource for all cell biologists and neuroscientists seeking to further understand the complex roles of ion channels in physiology and disease.<\/p>\n<p>Source :\u00a0 <a href=\"https:\/\/www.cshlpress.com\/default.tpl?cart=1571623068316310805&amp;action=full&amp;--eqskudatarq=1117\">https:\/\/www.cshlpress.com\/default.tpl?cart=1571623068316310805&amp;action=full&amp;&#8211;eqskudatarq=1117<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>AUTHOR :\u00a0 &#8211; CALL NO :\u00a0 QH603.I54 I64 2017 IMPRINT :\u00a0\u00a0 Cold Spring Harbor, NY : Cold Spring Harbor Laboratory Press, c2017<\/p>\n","protected":false},"author":1,"featured_media":5082,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[4],"tags":[168],"class_list":["post-5104","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-new-book-releases","tag-ion-channels"],"_links":{"self":[{"href":"https:\/\/stang.sc.mahidol.ac.th\/newresources\/index.php?rest_route=\/wp\/v2\/posts\/5104","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/stang.sc.mahidol.ac.th\/newresources\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/stang.sc.mahidol.ac.th\/newresources\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/stang.sc.mahidol.ac.th\/newresources\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/stang.sc.mahidol.ac.th\/newresources\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=5104"}],"version-history":[{"count":1,"href":"https:\/\/stang.sc.mahidol.ac.th\/newresources\/index.php?rest_route=\/wp\/v2\/posts\/5104\/revisions"}],"predecessor-version":[{"id":5105,"href":"https:\/\/stang.sc.mahidol.ac.th\/newresources\/index.php?rest_route=\/wp\/v2\/posts\/5104\/revisions\/5105"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/stang.sc.mahidol.ac.th\/newresources\/index.php?rest_route=\/wp\/v2\/media\/5082"}],"wp:attachment":[{"href":"https:\/\/stang.sc.mahidol.ac.th\/newresources\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=5104"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/stang.sc.mahidol.ac.th\/newresources\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=5104"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/stang.sc.mahidol.ac.th\/newresources\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=5104"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}