{"id":6109,"date":"2020-03-24T20:59:09","date_gmt":"2020-03-24T13:59:09","guid":{"rendered":"http:\/\/stang.sc.mahidol.ac.th\/newresources\/?p=6109"},"modified":"2020-03-24T20:59:09","modified_gmt":"2020-03-24T13:59:09","slug":"medicinal-chemistry-approaches-to-tuberculosis-and-trypanosomiasis","status":"publish","type":"post","link":"https:\/\/stang.sc.mahidol.ac.th\/newresources\/?p=6109","title":{"rendered":"Medicinal chemistry approaches to tuberculosis and trypanosomiasis"},"content":{"rendered":"<p><a href=\"https:\/\/library.mahidol.ac.th\/record=b1496718a\" target=\"_blank\" rel=\"noopener noreferrer\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft wp-image-6008 size-medium\" src=\"http:\/\/stang.sc.mahidol.ac.th\/newresources\/wp-content\/uploads\/2020\/03\/66782-202x300.jpg\" alt=\"\" width=\"202\" height=\"300\" \/><\/a><\/p>\n<p><strong>AUTHOR<\/strong> :\u00a0 &#8211;<\/p>\n<p><strong>CALL NO<\/strong> :\u00a0 W1 AN55 v.52 2019<\/p>\n<p><strong>IMPRINT<\/strong> :\u00a0\u00a0 Cambridge, Mass. : Elsevier\/Academic Press, c2019<\/p>\n<p><a href=\"http:\/\/stang.sc.mahidol.ac.th\/newresources\/wp-content\/uploads\/2020\/03\/W1-AN55-v.52-2019.pdf\" target=\"_blank\" rel=\"noopener noreferrer\"><strong>CLICK HERE FOR TABLE OF CONTENTS<\/strong><\/a><!--more--><\/p>\n<p>Some of the more recent efforts in tuberculosis (TB) and trypanosomiasis drug discovery from both Product Development Partnerships (PDPs) and academia are highlighted in this this volume. Drug discovery approaches include both target- and phenotypic whole cell screening- approaches. Regarding the latter, mechanism of action studies through target identification are also illustrated.<\/p>\n<p>Key Features<\/p>\n<ul>\n<li>Provides an overview of the status of some of the current novel compounds in development as well as new emerging treatment options targeting novel mechanisms of action<\/li>\n<li>Identification of hits from phenotypic whole cell screening, followed by target identification<\/li>\n<li>Strategies aimed at improving the efficacy of existing clinically used anti-TB drugs by taking advantage inhibitors of mycobacterial transcriptional regulators to boost the anti-tubercular activity, and circumvent acquired-resistance<\/li>\n<\/ul>\n<p>Source :\u00a0 <a href=\"https:\/\/www.elsevier.com\/books\/medicinal-chemistry-approaches-to-tuberculosis-and-trypanosomiasis\/chibale\/978-0-12-817556-9\">https:\/\/www.elsevier.com\/books\/medicinal-chemistry-approaches-to-tuberculosis-and-trypanosomiasis\/chibale\/978-0-12-817556-9<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>AUTHOR :\u00a0 &#8211; CALL NO :\u00a0 W1 AN55 v.52 2019 IMPRINT :\u00a0\u00a0 Cambridge, Mass. : Elsevier\/Academic Press, c2019 CLICK HERE FOR TABLE OF CONTENTS<\/p>\n","protected":false},"author":1,"featured_media":6008,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[965],"tags":[1064,155,1518,1517],"class_list":["post-6109","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-new-book-series-releases","tag-annual-reports-in-medicinal-chemistry","tag-book-series","tag-trypanosomiasis","tag-tuberculosis"],"_links":{"self":[{"href":"https:\/\/stang.sc.mahidol.ac.th\/newresources\/index.php?rest_route=\/wp\/v2\/posts\/6109","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/stang.sc.mahidol.ac.th\/newresources\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/stang.sc.mahidol.ac.th\/newresources\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/stang.sc.mahidol.ac.th\/newresources\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/stang.sc.mahidol.ac.th\/newresources\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=6109"}],"version-history":[{"count":2,"href":"https:\/\/stang.sc.mahidol.ac.th\/newresources\/index.php?rest_route=\/wp\/v2\/posts\/6109\/revisions"}],"predecessor-version":[{"id":6111,"href":"https:\/\/stang.sc.mahidol.ac.th\/newresources\/index.php?rest_route=\/wp\/v2\/posts\/6109\/revisions\/6111"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/stang.sc.mahidol.ac.th\/newresources\/index.php?rest_route=\/wp\/v2\/media\/6008"}],"wp:attachment":[{"href":"https:\/\/stang.sc.mahidol.ac.th\/newresources\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=6109"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/stang.sc.mahidol.ac.th\/newresources\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=6109"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/stang.sc.mahidol.ac.th\/newresources\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=6109"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}