Biomolecular thermodynamics : from theory to application
AUTHOR : Barrick, Douglas E.
CALL NO : QU34 B275b 2018
IMPRINT : Boca Raton, Fla. : CRC Press, c2018
This book provides a comprehensive, contemporary introduction to developing a quantitative understanding of how biological macromolecules behave using classical and statistical thermodynamics. The author focuses on practical skills needed to apply the underlying equations in real life examples. The text develops mechanistic models, showing how they connect to thermodynamic observables, presenting simulations of thermodynamic behavior, and analyzing experimental data. The reader is presented with plenty of exercises and problems to facilitate hands-on learning through mathematical simulation.
Features
- Emphasizes problem solving using both real and simulated data
- Develops multiple skill sets, including data analysis and mathematical simulation
- Covers various biochemical problems, including conformational equilibria, ligand binding, chemical denaturation, proton titration, helix-coil transition theory, allostery, and catalysis
- Offers a concise yet thorough and novel approach to understanding the essential aspects of physical chemistry without dry theoretical discussion
- Shows how to apply classical and statistical thermodynamics to complicated biochemical processes, such as ligand binding, cooperativity, and assembly
