The field of cytoskeletal research has advanced at a remarkable pace. Results obtained by many researchers scattered throughout the world have provided critically important insights into a wide range of cellular activities that go well beyond the locomotory activity of cells. This collection aims to capture the basic properties of each of the three major cytoskeletal systems: actin, intermediate filaments, and microtubules.
The collection is divided into five major parts and is preceded by an overview of the evolution of cytoskeletal systems. Part 1 contains descriptions of the structural proteins comprising the three major cytoskeletal systems, their associated motor proteins, and proteins involved in integrating the activities of the three systems. Part 2 is dedicated to the roles of cytoskeletal networks in determining cell and tissue architecture, cell adhesion, and the regulation of the mechanical properties of cells and includes an introduction to the more recent discoveries that the nucleus contains analogous nucleoskeletal proteins. In Parts 3 and 4, emphasis is placed on the intracellular transport of organelles and molecules involving the three cytoskeletal elements, as well as their roles in both muscle contraction and cell motility. Finally, Part 5 summarizes the advances that have taken place in our understanding of the roles of the cytoskeleton in mitosis and cytokinesis.
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