Natural-based polymers for biomedical applications
CALL NO : QT37.5.P7 N285 2017
IMPRINT : Oakville : Apple Academic Press, c2017
This book presents the authors’ biomedical studies of natural degradable biopolymers (polyhydroxyalkanoates [PHAs]) and discusses the demand for medical-grade materials and modern trends, focusing on the present status and future potential of PHAs. The authors present and summarize their most important results and findings obtained during the last few years in experimental studies and clinical trials of PHAs at the Institute of Biophysics Siberian Branch of Russian Academy of Science.
Almost all developed countries are now engaged in manufacturing PHAs or have plans to commercialize them, but the major factor that would allow wide-scale manufacture and use of PHAs is reduction of their cost. In Russia, the authors’ research team developed and tested the processes of high-yield production of polymers with different compositions on a variety of substrates (hydrogen, acetate, alcohols, and sugars) and prepared technological procedures for polymer production.
The polymers described and used in biomedical studies have been certified as suitable for medical use, including uses in contact with blood. Specifications of polymers with different chemical structure intended for use as a polymer basis for therapeutic systems, matrices of bio-artificial organs and implants, and packaging material have been developed and registered in Gosstandart of RF. Different types of PHAs were used to fabricate bio-inert films, membranes, and 3D constructs, which were tested as cell scaffolds for cellular and tissue engineering; microparticles, including those loaded with drugs; constructs and hybrid composites with hydroxyapatite for bone tissue repair. In cooperation with a number of medical clinics, the authors have been conducting clinical trials of polymer constructs as implants for bone tissue repair in orthopedics and oral surgery and have developed and are now testing biocompatible polymer-coated vascular stents. An approach to engineering and scale-up of polyhydroxyalkanoate synthesis facility has also been developed.
The goal of this book is to show current world trends in research of this type of biomaterials, the position and potential of polyhydroxyalkanoates, and to summarize results of experimental tests and clinical trials of PHAs obtained in the last few years at the Institute of Biophysics SB RAS, Siberian Federal University, and V. F. Voino-Yasenetsky Krasnoyarsk Federal Medical University. The book presents results of research in modern biotechnology aimed at the creation of sustained-release drug delivery systems and constructs for cellular and tissue engineering and for reconstructive medicine.
The book is intended for biotechnologists, material scientists, medical practitioners, and teachers and students of biological and medical departments of universities.